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Article

Targeting of human catalase to peroxisomes is dependent upon a novel COOH-terminal peroxisomal targeting sequence.

The Journal of cell biology - 1 Aug 1996

Purdue P E, Lazarow P B

Abstract excerpt

We have identified a novel peroxisomal targeting sequence (PTS) at the extreme COOH terminus of human catalase. The last four amino acids of this protein (-KANL) are necessary and sufficient to effect targeting to peroxisomes in both human fibroblasts and Saccharomyces cerevisiae, when appended to the COOH terminus of the reporter protein, chloramphenicol acetyl transferase. However, this PTS differs from the...

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Identifiers

PMID: 8769411
DOI: 10.1083/jcb.134.4.849
PMCID: PMC2120961

Genes

PTS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Targeting of human catalase to peroxisomes is dependent upon a novel COOH-terminal peroxisomal targeting sequence.PMID 8769411Read ↗

Pex5p imports folded tetrameric catalase by interaction with Pex13p.Semantic proximity Read ↗

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The peroxisomal import receptor PEX5 functions as a stress sensor, retaining catalase in the cytosol in times of oxidative stress.Semantic proximity Read ↗

Identification of sequences required for the import of human protoporphyrinogen oxidase to mitochondria.Semantic proximity Read ↗

The relevance of the non-canonical PTS1 of peroxisomal catalase.Semantic proximity Read ↗

Mistargeting of peroxisomal L-alanine:glyoxylate aminotransferase to mitochondria in primary hyperoxaluria patients depends upon activation of a cryptic mitochondrial targeting sequence by a point mutation.Semantic proximity Read ↗

The import receptor for the peroxisomal targeting signal 2 (PTS2) in Saccharomyces cerevisiae is encoded by the PAS7 gene.Semantic proximity Read ↗

The pas8 mutant of Pichia pastoris exhibits the peroxisomal protein import deficiencies of Zellweger syndrome cells--the PAS8 protein binds to the COOH-terminal tripeptide peroxisomal targeting signal, and is a member of the TPR protein family.Semantic proximity Read ↗

Peroxisome targeting signal type 1 (PTS1) receptor is involved in import of both PTS1 and PTS2: studies with PEX5-defective CHO cell mutants.Semantic proximity Read ↗

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