Article
Human peroxisomal L-alanine: glyoxylate aminotransferase. Evolutionary loss of a mitochondrial targeting signal by point mutation of the initiation codon.
The Biochemical journal - 1 Jun 1990
Takada Y, Kaneko N, Esumi H, Purdue P E, Danpure C J
Abstract excerpt
The amino acid sequence of human hepatic peroxisomal L-alanine: glyoxylate aminotransferase 1 (AGTI) deduced from cDNA shows 78% sequence identity with that of rat mitochondrial AGTI, but lacks the N-terminal 22 amino acids (the putative mitochondrial targeting signal). In humans this signal appe...
Topics
- Alanine Transaminase
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Evolution
- Codon
- DNA, Mitochondrial
- DNA, Recombinant
- Humans
- Hyperoxaluria
- Microbodies
- Mitochondria
- Molecular Sequence Data
- Mutation
- RNA, Messenger
- Rats
- Transaminases