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Article

Differential protein import deficiencies in human peroxisome assembly disorders.

The Journal of cell biology - 1 May 1994

Motley A, Hettema E, Distel B, Tabak H

Abstract excerpt

Two peroxisome targeting signals (PTSs) for matrix proteins have been well defined to date. PTS1 comprises a COOH-terminal tripeptide, SKL, and has been found in several matrix proteins, whereas PTS2 has been found only in peroxisomal thiolase and is contained within an NH2-terminal cleavable presequence. We have investigated the functional integrity of the import routes for PTS1 and PTS2 in fibroblasts from...

Topics

Acetyl-CoA C-Acetyltransferase
Biological Transport
Cells, Cultured
Endopeptidases
Fibroblasts
Genetic Complementation Test
Humans
Metabolic Diseases
Microbodies
Phenotype
Protein Sorting Signals

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Signal Transduction

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Identifiers

PMID: 7910611
DOI: 10.1083/jcb.125.4.755
PMCID: PMC2120069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7910611-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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