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Article

Peroxisome targeting signal type 1 (PTS1) receptor is involved in import of both PTS1 and PTS2: studies with PEX5-defective CHO cell mutants.

Molecular and cellular biology - 1 Jan 1998

Otera H, Okumoto K, Tateishi K, Ikoma Y, Matsuda E, Nishimura M, Tsukamoto T, Osumi T, Ohashi K, Higuchi O, Fujiki Y

Abstract excerpt

To investigate the mechanisms of peroxisome assembly and the molecular basis of peroxisome assembly disorders, we isolated and characterized a peroxisome-deficient CHO cell mutant, ZP139, which was found to belong to human complementation group II, the same group as that of our earlier mutant, ZP...

Topics

Amino Acid Sequence
Animals
CHO Cells
Cricetinae
Fungal Proteins
Gene Expression Regulation
Humans
Microbodies
Molecular Sequence Data
Mutation
Peroxisomal Targeting Signal 2 Receptor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Peroxisome-Targeting Signal 1 Receptor

Receptors, Cytoplasmic and Nuclear

Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 9418886
DOI: 10.1128/MCB.18.1.388
PMCID: PMC121509

Genes

PEX5
TPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9418886-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Peroxisome targeting signal type 1 (PTS1) receptor is involved in import of both PTS1 and PTS2: studies with PEX5-defective CHO cell mutants.PMID 9418886Read ↗

Pex5p stabilizes Pex14p: a study using a newly isolated pex5 CHO cell mutant, ZPEG101.Semantic proximity Read ↗

Interaction defect of the medium isoform of PTS1-receptor Pex5p with PTS2-receptor Pex7p abrogates the PTS2 protein import into peroxisomes in mammals.Semantic proximity Read ↗

Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders.Semantic proximity Read ↗

Molecular mechanisms of import of peroxisome-targeting signal type 2 (PTS2) proteins by PTS2 receptor Pex7p and PTS1 receptor Pex5pL.Semantic proximity Read ↗

Cysteine ubiquitination of PTS1 receptor Pex5p regulates Pex5p recycling.Semantic proximity Read ↗

Intracellular localization, function, and dysfunction of the peroxisome-targeting signal type 2 receptor, Pex7p, in mammalian cells.Semantic proximity Read ↗

A temperature-sensitive CHO pex1 mutant with a novel mutation in the AAA Walker A1 motif.Semantic proximity Read ↗

Genotype-phenotype correlation in PEX5-deficient peroxisome biogenesis defective cell lines.Semantic proximity Read ↗

Isolation of a new peroxisome-deficient CHO cell mutant defective in peroxisome targeting signal-1 receptor.Semantic proximity Read ↗

Peroxisome biogenesis and molecular defects in peroxisome assembly disorders.Semantic proximity Read ↗

Functional heterogeneity of C-terminal peroxisome targeting signal 1 in PEX5-defective patients.Semantic proximity Read ↗

Mutations in PEX1 are the most common cause of peroxisome biogenesis disorders.Semantic proximity Read ↗

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