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Article

Combined pituitary hormone deficiency in Australian children: clinical and genetic correlates.

Clinical endocrinology - 1 Jun 2003

McLennan Kim, Jeske Yvette, Cotterill Andrew, Cowley David, Penfold James, Jones Tim, Howard Neville, Thomsett Michael, Choong Catherine

Abstract excerpt

OBJECTIVE: Mutations in the gene for the POU domain transcription factor POU1F1 (human Pit-1) have been reported in patients with GH, TSH and PRL deficiencies. PROP1 (Prophet of Pit-1) gene mutations also cause gonadotrophin deficiencies and in some cases partial ACTH deficiency. This study analyses the POU1F1 and PROP1 genes in a cohort of Australian children with combined pituitary hormone deficiency (CPHD) and...

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Source

Identifiers

PMID: 12780757
DOI: 10.1046/j.1365-2265.2003.01781.x

Genes

PROP1
PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Combined pituitary hormone deficiency in Australian children: clinical and genetic correlates.PMID 12780757Read ↗

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