Article
Inorganic, monovalent cations compete with agonists for the transmitter binding site of nicotinic acetylcholine receptors.
Biophysical journal - 1 Jun 1996
Akk G, Auerbach A
Abstract excerpt
The properties of adult mouse recombinant nicotinic acetylcholine receptors activated by acetylcholine (ACh+) or tetramethylammonium (TMA+) were examined at the single-channel level. The midpoint of the dose-response curve depended on the type of monovalent cation present in the extracellular solution. The shifts in the midpoint were apparent with both inward and outward currents, suggesting that the salient...
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