Article
Paraoxonase: biochemistry, genetics and relationship to plasma lipoproteins.
Current opinion in lipidology - 1 Apr 1996
Mackness M I, Mackness B, Durrington P N, Connelly P W, Hegele R A
Abstract excerpt
Human serum paraoxonase is located on an HDL. It has the capacity to retard the accumulation of lipid peroxides in LDL under oxidizing conditions in vitro. Paraoxonase has a genetic polymorphism that results in a single amino acid substitution. Evidence indicates that both the serum concentration of paraoxonase and an individual's genotype are related to plasma lipid and lipoprotein concentrations, and possibly...
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