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Article

Genetic changes in the origin and development of renal cell carcinoma (RCC).

Pflugers Archiv : European journal of physiology - 1 Jan 1996

Glavac D, Ravnik-Glavac M, Ovcak Z, Masera A

Abstract excerpt

64 kidney tumours of clear cell histopathology were analysed with non-isotopic SSCP and HA for the presence of VHL gene defects. All positive cases were further characterised by direct sequencing. In 30 tumours (48%) mutations were identified in the coding region of the VHL gene. Other tumours were examined for methylation changes in 5' CpG islands in exon 1 Bisulphite genomic sequencing which gives positive...

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Source

Identifiers

PMID: 8739330
DOI: 10.1007/BF02346334

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic changes in the origin and development of renal cell carcinoma (RCC).PMID 8739330Read ↗

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