Article
Biological phenotype of HIV type 2 isolates correlates with V3 genotype.
AIDS research and human retroviruses - 10 Jun 1996
Albert J, Stålhandske P, Marquina S, Karis J, Fouchier R A, Norrby E, Chiodi F
Abstract excerpt
The biological phenotype of HIV-2 isolates can be divided into two groups, rapid/high and slow/low, based on the ability to infect CD4+ tumor cell lines. Similar differences in the biological phenotype of HIV-1 isolates are largely determined by the charge of two specific amino acids in the V3 loop of the envelope protein gp120. In this study we have sequenced the V3 loop and flanking regions of 14 HIV-2 isolates...
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