Article
Indian primary HIV-2 isolates and relationship between V3 genotype, biological phenotype and coreceptor usage.
Virology - 20 Jun 2005
Kulkarni Smita, Tripathy Srikanth, Agnihotri Kalpana, Jatkar Neena, Jadhav Sushama, Umakanth Winston, Dhande Kavita, Tondare Prasad, Gangakhedkar Raman, Paranjape Ramesh
Abstract excerpt
The chemokine coreceptors play a significant role in HIV entry and pathogenesis. The V3 region of HIV envelope glycoprotein is considered as a principal determinant for viral phenotype and tropism. The present study describes lack of association between the V3 genotype and viral phenotype of 18 Indian HIV-2 isolates. The viruses were isolated, confirmed by PCR and the HIV subtypes were determined by sequencing V3...
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