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Article

Activated protein C resistance phenotype and genotype in patients with primary antiphospholipid syndrome.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis - 1 Apr 1996

Ruiz-Argüelles G J, Garcés-Eisele J, Alarcón-Segovia D, Ruiz-Argüelles A

Abstract excerpt

We studied both inherited and acquired activated protein C (APC) resistance in a group of 22 patients with primary antiphospholipid syndrome (APS). The APC resistance genotype was assessed using a PCR-based analysis for the factor V R506Q (Leiden) mutation. One patient with primary APS was found to be heterozygous for the factor V Leiden mutation. He and other family members were affected by severe thrombophilia...

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Identifiers

PMID: 8735142
DOI: 10.1097/00001721-199604000-00009

Genes

APC

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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