Article
Patients with persistent APC-resistance without factor V Leiden mutation.
VASA. Zeitschrift fur Gefasskrankheiten - 1 Feb 2001
Schwarz T, Siegert G, Mikulin U, Gehrisch S, Runge E, Berg L P, Koch R, Schellong S M
Abstract excerpt
BACKGROUND: Activated protein C (APC) resistance and factor V Leiden mutation are major risk factors for deep venous thrombosis. Previous work has led to the view that the coagulation phenotype and the genetic defect are associated in almost all patients. It has been reported about single APC-resistant patients without associated factor V Leiden, but significance and thrombotic risk of this constellation have not...
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