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Article

Molecular characterization of a type I quantitative factor V deficiency in a thrombosis patient that is "pseudo homozygous" for activated protein C resistance.

Thrombosis and haemostasis - 1 Feb 1997

Guasch J F, Lensen R P, Bertina R M

Abstract excerpt

Resistance to activated protein C (APC), which is associated with the FV Leiden mutation in the large majority of the cases, is the most common genetic risk factor for thrombosis. Several laboratory tests have been developed to detect the APC-resistance phenotype. The result of the APC-resistance test (APC-sensitivity ratio, APC-SR) usually correlates well with the FV Leiden genotype, but recently some...

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Identifiers

PMID: 9157576

Genes

APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Molecular characterization of a type I quantitative factor V deficiency in a thrombosis patient that is "pseudo homozygous" for activated protein C resistance.PMID 9157576Read ↗

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"Pseudo homozygous" activated protein C resistance due to double heterozygous factor V defects (factor V Leiden mutation and type I quantitative factor V defect) associated with thrombosis: report of two cases belonging to two unrelated kindreds.Semantic proximity Read ↗

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Inherited resistance to activated protein C, a major cause of venous thrombosis, is due to a mutation in the factor V gene.Semantic proximity Read ↗

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Congenital and acquired activated protein C resistance.Semantic proximity Read ↗

Early days of APC resistance and FV Leiden.Semantic proximity Read ↗

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New molecular insights into the genetics of thrombophilia. Resistance to activated protein C caused by Arg506 to Gln mutation in factor V as a pathogenic risk factor for venous thrombosis.Semantic proximity Read ↗

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Resistance to activated protein C caused by the factor VR506Q mutation is a common risk factor for venous thrombosis.Semantic proximity Read ↗

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