Structural characterization of variant forms of arylsulfatase A that associate with alcoholism.

doi:10.1111/j.1530-0277.1996.tb01635.x

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Article

Structural characterization of variant forms of arylsulfatase A that associate with alcoholism.

Alcoholism, clinical and experimental research - 1 Apr 1996

Park D S, Manowitz P, Stein S, Poretz R D

Abstract excerpt

Several electrophoretic forms of human platelet arylsulfatase A (ASA), including variant type IIIa and normal type IV(a), have been identified by nondenaturing polyacrylamide gel electrophoresis. An alcoholic population that we have analyzed is enriched in variant type IIIa compared with nonalcoh...

Topics

Alcoholism
Blood Platelets
Cerebroside-Sulfatase
Fibroblasts
Genetic Variation
Glycosylation
Humans
Isoenzymes
Leukodystrophy, Metachromatic
Protein Processing, Post-Translational

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