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Article

The interaction of lead exposure and arylsulfatase A genotype affects sulfatide catabolism in human fibroblasts.

Neurotoxicology - 1 Jun 2000

Poretz R D, Yang A, Deng W, Manowitz P

Abstract excerpt

Lead exposure causes cognitive and behavioral deficits in some affected children. We propose that a contributing mechanism for the neurological damage is that lead induces critically low levels of arylsulfatase A (ASA) at sensitive stages of nervous system development. It is hypothesized that the combined effects of a single nucleotide polymorphism (SNP) in human ASA which results in reduced levels of the enzyme,...

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PMID: 10894127

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The interaction of lead exposure and arylsulfatase A genotype affects sulfatide catabolism in human fibroblasts.PMID 10894127Read ↗

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