Article
Evidence for an N-glycosylation polymorphism of arylsulfatase a predisposing to alcoholism in Koreans.
American journal of medical genetics - 8 Mar 2002
Chung In-Won, Kim Heon, Lee Sang-Ick, Hong Joo-Bong, Kim Yong-Dae, Nan Hong-Mei, Sribney William, Kim Yong-Sik, Manowitz Paul
Abstract excerpt
This study investigated the possible effect of the pseudodeficient N-glycosylation polymorphism of the arylsulfatase A (ASA) gene on alcohol dependence among Koreans. Alcoholic patients (N=123) were more likely than control subjects to be heterozygous or homozygous for the ASA pseudodeficient N-glycosylation site (36% of alcoholics versus 20% of controls; P<0.01). Among these 123 alcoholic patients, 42 alcoholics...
Topics
- Alcoholism
- Binding Sites
- Cerebroside-Sulfatase
- DNA
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Glycosylation
- Korea
- Polymorphism, Genetic