Article
A novel arylsulfatase A protein variant and genotype in two patients with major depression.
Journal of affective disorders - 14 Oct 1996
Ricketts M H, Amsterdam J D, Park D S, Yang R S, Poretz R D, Zhang X, Fanale M, Baddoo A, Manowitz P
Abstract excerpt
A new, 'diffuse, multiple banding', electrophoretic variant of arylsulfatase A protein was found in two patients with major depression. Protein analyses showed that this variant and the normal enzyme differed in amino acid sequence and/or post-translational modifications unrelated to phosphate gr...
Topics
- Adult
- Aged
- Blood Protein Electrophoresis
- Cerebroside-Sulfatase
- DNA Mutational Analysis
- Depressive Disorder
- Female
- Genetic Variation
- Humans
- Isoenzymes
- Leukodystrophy, Metachromatic
- Male