Article
Association of alcoholism with the N-glycosylation polymorphism of pseudodeficient human arylsulfatase A.
Alcoholism, clinical and experimental research - 1 Apr 1996
Park D S, Poretz R D, Stein S, Nora R, Manowitz P
Abstract excerpt
The IIIa and IIIb electrophoretic variants of arylsulfatase A (EC 3.1.6.8) are 12 times more prevalent in alcoholic than in nonalcoholic populations. These variant enzymes, found in a subset of alcoholics, possess the pseudodeficient Asn350-Ser mutation of arylsulfatase A and, consequently, lack...
Topics
- Adult
- Alcoholism
- Cerebroside-Sulfatase
- Female
- Genotype
- Glycosylation
- Humans
- Isoenzymes
- Leukodystrophy, Metachromatic
- Male
- Mental Disorders
- Middle Aged
- Phenotype