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Article

The Fok1 vitamin D receptor gene polymorphism is associated with plasma renin activity in Caucasians.

Clinical endocrinology - 1 Jun 2011

Vaidya Anand, Sun Bei, Forman John P, Hopkins Paul N, Brown Nancy J, Kolatkar Nikheel S, Williams Gordon H, Williams Jonathan S

Abstract excerpt

OBJECTIVES: 25-Hydroxyvitamin D (25(OH)D) deficiency and excess activity of the renin-angiotensin system (RAS) are both associated with cardiovascular disease. Vitamin D interacts with the vitamin D receptor (VDR) to negatively regulate renin expression in mice; however, human studies linking genetic variation in the VDR with renin are lacking. We evaluated (i) whether genetic variation in the VDR at the Fok1...

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Source

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Identifiers

PMID: 21521263
DOI: 10.1111/j.1365-2265.2011.03991.x
PMCID: PMC3089671

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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