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Article

Reversion to wildtype of a mutated and nonfunctional coxsackievirus B3CRE(2C).

Virus research - 15 Jul 2016

Smithee Shane, Tracy Steven, Chapman Nora M

Abstract excerpt

The cis-acting replication element (CRE) in the 2C protein coding region [CRE(2C)] of enteroviruses (EV) facilitates the addition of two uridine residues (uridylylation) onto the virus-encoded protein VPg in order for it to serve as the RNA replication primer. We demonstrated that coxsackievirus B3 (CVB3) is replication competent in the absence of a native (uridylylating) CRE(2C) and also demonstrated that lack...

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Identifiers

PMID: 27130630
DOI: 10.1016/j.virusres.2016.04.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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