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Article

Altered pathway routing in a class of Salmonella enterica serovar Typhimurium mutants defective in aminoimidazole ribonucleotide synthetase.

Journal of bacteriology - 1 Apr 2001

Zilles J L, Kappock T J, Stubbe J, Downs D M

Abstract excerpt

In Salmonella enterica serovar Typhimurium, purine nucleotides and thiamine are synthesized by a branched pathway. The last known common intermediate, aminoimidazole ribonucleotide (AIR), is formed from formylglycinamidine ribonucleotide (FGAM) and ATP by AIR synthetase, encoded by the purI gene in S. enterica. Reduced flux through the first five steps of de novo purine synthesis results in a requirement for...

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Identifiers

PMID: 11244062
DOI: 10.1128/JB.183.7.2234-2240.2001
PMCID: PMC95129

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