Article
A two-allele polymorphism in protein C inhibitor with varying frequencies in different ethnic populations.
Thrombosis and haemostasis - 1 Jan 1996
Radtke K P, Greengard J S, Fernández J A, Villoutreix B O, Griffin J H
Abstract excerpt
cDNAs for protein C inhibitor (PCI), prepared from human liver RNA, contained two forms of PCI, designated PCI*A and PCI*B. While PCI*A is identical to the published PCI sequence, PCI*B differs in 4 of 1221 bp and two amino acids, A36V and K86E. Frequencies for the PCI*B allele, determined from genomic DNA, differed among ethnic groups. Frequency distribution and historical migration of modern man suggest that...
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