Effect of single amino acid substitutions on the formation of the PlA and Bak alloantigenic epitopes.

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Article

Effect of single amino acid substitutions on the formation of the PlA and Bak alloantigenic epitopes.

Blood - 1 Aug 1991

Goldberger A, Kolodziej M, Poncz M, Bennett J S, Newman P J

Abstract excerpt

The subunits that comprise the platelet-specific integrin alpha IIb beta 3 are polymorphic in nature, with several allelic forms present in the human gene pool. Minor changes in the secondary and tertiary structures of platelet membrane glycoproteins (GP) IIb and IIIa encoded by these alleles can...

Topics

Alleles
Amino Acid Sequence
Antigens, Human Platelet
Blood Platelets
Epitopes
Genetic Vectors
Humans
Integrin beta3
Integrins
Isoantigens
Leucine
Macromolecular Substances
Molecular Sequence Data
Platelet Membrane Glycoproteins
Polymerase Chain Reaction
RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 1713513

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1713513-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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