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Article

Establishment of a 5-fluorouracil-resistant triple-negative breast cancer cell line

10 Oct 2013

Abstract excerpt

Triple-negative breast cancers (TNBCs) are defined as tumors that lack expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2. Clinically, TNBC patients are treated with cytotoxic drugs including 5-fluorouracil (5-FU). However, TNBCs develop resistance to such drugs after a series of treatments. To elucidate the mechanisms of drug resistance, establishment of...

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PMID: 24126575
DOI: 10.3892/ijo.2013.2135

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