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Article

ZP3-dependent activation of sperm cation channels regulates acrosomal secretion during mammalian fertilization.

1 Aug 1996

Abstract excerpt

The sperm acrosome reaction is a Ca(2+)-dependent secretory event required for fertilization. Adhesion to the egg's zona pellucida promotes Ca2+ influx through voltage-sensitive channels, thereby initiating secretion. We used potentiometric fluorescent probes to determine the role of sperm membrane potential in regulating Ca2+ entry. ZP3, the glycoprotein agonist of the zona pellucida, depolarizes sperm membranes...

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Identifiers

PMID: 8707844
DOI: 10.1083/jcb.134.3.637

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