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Article

Modulation of virulence factor expression by pathogen target cell contact.

Science (New York, N.Y.) - 30 Aug 1996

Pettersson J, Nordfelth R, Dubinina E, Bergman T, Gustafsson M, Magnusson K E, Wolf-Watz H

Abstract excerpt

Upon contact with the eukaryotic cell, Yersinia pseudotuberculosis increased the rate of transcription of virulence genes (yop), as determined by in situ monitoring of light emission from individual bacteria expressing luciferase under the control of the yopE promoter. The microbe-host interaction triggered export of LcrQ, a negative regulator of Yop expression, via the Yop-type III secretion system. The...

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Identifiers

PMID: 8703058
DOI: 10.1126/science.273.5279.1231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Modulation of virulence factor expression by pathogen target cell contact.PMID 8703058Read ↗

Translocation of surface-localized effectors in type III secretion.Semantic proximity Read ↗

The V-antigen of Yersinia is surface exposed before target cell contact and involved in virulence protein translocation.Semantic proximity Read ↗

Diminished LcrV secretion attenuates Yersinia pseudotuberculosis virulence.Semantic proximity Read ↗

YopK of Yersinia pseudotuberculosis controls translocation of Yop effectors across the eukaryotic cell membrane.Semantic proximity Read ↗

The type III secretion chaperone LcrH co-operates with YopD to establish a negative, regulatory loop for control of Yop synthesis in Yersinia pseudotuberculosis.Semantic proximity Read ↗

A novel protein, LcrQ, involved in the low-calcium response of Yersinia pseudotuberculosis shows extensive homology to YopH.Semantic proximity Read ↗

Real-time characterization of virulence factor expression in Yersinia pestis using a GFP reporter system.Semantic proximity Read ↗

YscB of Yersinia pestis functions as a specific chaperone for YopN.Semantic proximity Read ↗

Evidence for targeting of Yop effectors by the chromosomally encoded Ysa type III secretion system of Yersinia enterocolitica.Semantic proximity Read ↗

The gatekeeper of <i>Yersinia</i> type III secretion is under RNA thermometer controlSemantic proximity Read ↗

The V antigen of Yersinia pestis regulates Yop vectorial targeting as well as Yop secretion through effects on YopB and LcrG.Semantic proximity Read ↗

Comparative analysis of type III effector translocation by Yersinia pseudotuberculosis expressing native LcrV or PcrV from Pseudomonas aeruginosa.Semantic proximity Read ↗

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