Article
Detection of t(2;5)(p23;q35) translocation by reverse transcriptase polymerase chain reaction and in situ hybridization in CD30-positive primary cutaneous lymphoma and lymphomatoid papulosis.
The American journal of pathology - 1 Aug 1996
Beylot-Barry M, Lamant L, Vergier B, de Muret A, Fraitag S, Delord B, Dubus P, Vaillant L, Delaunay M, MacGrogan G, Beylot C, de Mascarel A, Delsol G, Merlio J P
Abstract excerpt
The t(2;5) generates a chimeric NPM-ALK transcript encoded by the nucleophosmin NPM gene fused to the anaplastic lymphoma kinase gene ALK. Using a reverse transcriptase nested polymerase chain reaction assay we have detected NPM-ALK transcripts within CD30+ primary cutaneous lymphoma and lymphomatoid papulosis (LP). The t(2;5) was identified in 4 out of 9 CD30+ anaplastic lymphomas and in 1 out of 4 CD30+...
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