Article
A novel recurrent NPM1-TYK2 gene fusion in cutaneous CD30-positive lymphoproliferative disorders.
Blood - 11 Dec 2014
Velusamy Thirunavukkarasu, Kiel Mark J, Sahasrabuddhe Anagh A, Rolland Delphine, Dixon Catherine A, Bailey Nathanael G, Betz Bryan L, Brown Noah A, Hristov Alexandra C, Wilcox Ryan A, Miranda Roberto N, Medeiros L Jeffrey, Jeon Yoon K, Inamdar Kedar V, Lim Megan S, Elenitoba-Johnson Kojo S J
Abstract excerpt
The spectrum of cutaneous CD30-positive lymphoproliferative disorders (LPDs) includes lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma. Chromosomal translocations targeting tyrosine kinases in CD30-positive LPDs have not been described. Using whole-transcriptome sequencing, we identified a chimeric fusion involving NPM1 (5q35) and TYK2 (19p13) that encodes an NPM1-TYK2 protein...
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