Article
Hemoglobin S/hemoglobin Osler: a case with 3 beta globin chains. DNA sequence (AAT) proves that Hb Osler is beta 145 Tyr-->Asn.
American journal of hematology - 1 Aug 1996
Hutt P J, Donaldson M H, Khatri J, Fairbanks V F, Hoyer J D, Thibodeau S N, Moxness M S, McMorrow L E, Green M M, Jones R T
Abstract excerpt
A 13-year-old African-American female with erythrocytosis and three different beta globins on electrophoresis beta A, beta S, and beta Osler, raised the possibility that one chromosome 11 might contain a duplicated beta globin gene, since there are normally only 2 beta globin genes. DNA sequence...
Topics
- Adolescent
- Base Sequence
- Chromosomes, Human, Pair 11
- DNA
- Exons
- Female
- Globins
- Hemoglobin, Sickle
- Hemoglobins, Abnormal
- Humans
- Molecular Sequence Data
- Mutation
- Sequence Analysis, DNA
- Twins, Dizygotic