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Article

Hb Nancy and Hb Osler: two distinct genetic variants with identical clinical and hemoglobin phenotype.

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie - 1 May 1998

Préhu C, Godart C, Vigneron C, Wajcman H

Abstract excerpt

Three hemoglobin variants (Hb Nancy, Osler and Fort Gordon), carrying the same Tyr-->Asp substitution at position beta 145 (HC2), have been independently described in 1975 in patients with marked polycythemia. The first one was found in a French caucasian family from Lorraine, and the two others in African Americans. Two unrelated individuals with Hb Osler have been recently reinvestigated at the DNA level and...

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PMID: 9766188
DOI: 10.1016/s0764-4469(98)80300-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Click a neighbor to travelStep 1 · 12 closest

Hb Nancy and Hb Osler: two distinct genetic variants with identical clinical and hemoglobin phenotype.PMID 9766188Read ↗

Four new variants of the alpha2-globin gene without clinical or hematologic effects: Hb Park Ridge [alpha9(alpha7)Asn-->Lys (alpha2)], Hb Norton [alpha72(EF1)His-->Asp (alpha2)], Hb Lombard [alpha103(G10)His-->Tyr (alpha2)], and Hb San Antonio [A113(GH2)Leu-->Arg (A2)].Semantic proximity Read ↗

Hb-Alberta or alpha2beta2 (101(G3) Glu replaced by Gly), a new high-oxygen-affinity hemoglobin variant causing erythrocytosis.Semantic proximity Read ↗

Hemoglobin S/hemoglobin Osler: a case with 3 beta globin chains. DNA sequence (AAT) proves that Hb Osler is beta 145 Tyr-->Asn.Semantic proximity Read ↗

Two new alpha chain variants: Hb Boghé [alpha58(E7)His-->Gln, alpha2], a variant on the distal histidine, and Hb CHarolles [alpha103(G10)His-Tyr, alpha1].Semantic proximity Read ↗

A novel beta-globin variant: Hb Poços de Caldas [beta 61(E5)Lys-->Gln].Semantic proximity Read ↗

Hemoglobin Birmingham and hemoglobin Galicia: two unstable beta chain variants characterized by small deletions and insertions.Semantic proximity Read ↗

Hb Saint Nazaire (beta 103[G5]Phe-->Ile): a new example of polycythemia due to a hemoglobin variant with increased oxygen affinity.Semantic proximity Read ↗

Hb Kodaira II: a high oxygen affinity variant with a novel mutation in the beta-globin gene and phenotypic identity to Hb Kodaira.Semantic proximity Read ↗

Hemoglobin Rouen (alpha-140 (HC2) Tyr-->His): alteration of the alpha-chain C-terminal region and moderate increase in oxygen affinity.Semantic proximity Read ↗

Hb Watford [beta1(NA1)Val-->Gly]: a new, clinically silent hemoglobin variant in linkage with a new neutral mutation.Semantic proximity Read ↗

Two new G gamma chain variants: Hb F-Saint-Etienne [G gamma 79(EF3)Asp-->His] and Hb F-Lyon [G gamma 97(FG4)His-->Arg].Semantic proximity Read ↗

Two new human hemoglobin variants caused by unusual mutational events: Hb Zaïre contains a five residue repetition within the alpha-chain and Hb Duino has two residues substituted in the beta-chain.Semantic proximity Read ↗

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