Heerlen polymorphism of protein S, an immunologic polymorphism due to dimorphism of residue 460.

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Article

Heerlen polymorphism of protein S, an immunologic polymorphism due to dimorphism of residue 460.

Blood - 1 Aug 1990

Bertina R M, Ploos van Amstel H K, van Wijngaarden A, Coenen J, Leemhuis M P, Deutz-Terlouw P P, van der Linden I K, Reitsma P H

Abstract excerpt

We recently developed an enzyme-linked immunosorbent assay (ELISA) for total protein S (PS) antigen using the monoclonal antibody S-12. During the screening of thrombophilic patients we identified a patient, who was using marcoumar, with 0% PS by monoclonal ELISA and 23% PS by polyclonal ELISA. F...

Topics

Adult
Alleles
Amino Acid Sequence
Amino Acids
Antibodies, Monoclonal
Base Sequence
Blood Donors
Cytosine
Enzyme-Linked Immunosorbent Assay
Female
Gene Frequency
Genotype
Glycoproteins
Glycosylation
Humans
Male
Molecular Sequence Data
Mutation

Source

Open in PubMed

Identifiers

PMID: 2143091

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-2143091-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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