Article
Epstein-Barr virus from Burkitt Lymphoma biopsies from Africa and South America share novel LMP-1 promoter and gene variations.
Scientific reports - 23 Nov 2015
Lei Haiyan, Li Tianwei, Li Bingjie, Tsai Shien, Biggar Robert J, Nkrumah Francis, Neequaye Janet, Gutierrez Marina, Epelman Sidnei, Mbulaiteye Sam M, Bhatia Kishor, Lo Shyh-Ching
Abstract excerpt
Epstein Barr virus (EBV) sequence variation is thought to contribute to Burkitt lymphoma (BL), but lack of data from primary BL tumors hampers efforts to test this hypothesis. We directly sequenced EBV from 12 BL biopsies from Ghana, Brazil, and Argentina, aligned the obtained reads to the wild-type (WT) EBV reference sequence, and compared them with 100 published EBV genomes from normal and diseased people from...
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