Article
Different fates of Legionella pneumophila pmi and mil mutants within macrophages and alveolar epithelial cells.
Microbial pathogenesis - 1 Dec 1998
Gao L Y, Stone B J, Brieland J K, Abu Kwaik Y
Abstract excerpt
Alveolar epithelial cells, which constitute the majority of the alveolar surface, may represent a potential niche for intracellular replication of Legionella pneumophila that has been largely overlooked. We examined the phenotypes of a bank of 121 macrophage-defective mutants of L. pneumophila (d...
Topics
- Animals
- Bacterial Adhesion
- Cell Line
- Epithelial Cells
- HeLa Cells
- Humans
- Legionella pneumophila
- Macrophages, Alveolar
- Mice
- Mice, Inbred A
- Mice, Knockout
- Microscopy, Electron
- Mutation
- Phenotype
- Pulmonary Alveoli
- U937 Cells
- Virulence