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Article

Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study.

Blood - 1 Jul 1990

Crist W M, Carroll A J, Shuster J J, Behm F G, Whitehead M, Vietti T J, Look A T, Mahoney D, Ragab A, Pullen D J

Abstract excerpt

The prognostic significance of chromosomal translocations, particularly t(1;19) (q23;p13), was evaluated in children with pre-B and early pre-B acute lymphoblastic leukemia (ALL). Patients were treated on a risk-based protocol of the Pediatric Oncology Group (POG) between February 1986 and May 1989. An abnormal clone was detected in 46% (130 of 285) of pre-B cases and 56% (380 of 679) of early pre-B cases....

Topics

B-Lymphocytes
Child
Child, Preschool
Chromosomes, Human, Pair 1
Chromosomes, Human, Pair 19
Female
Humans
Infant
Infant, Newborn
Male
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Prognosis

Stem Cells

Translocation, Genetic

Source

Identifiers

PMID: 2364165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2364165-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study.PMID 2364165Read ↗

Cytogenetics of pre-B-cell acute lymphoblastic leukemia with emphasis on prognostic implications of the t(1;19).Semantic proximity Read ↗

Immunologic, cytogenetic, and clinical characterization of childhood acute lymphoblastic leukemia with the t(1;19) (q23; p13) or its derivative.Semantic proximity Read ↗

Paediatric B‐cell precursor acute lymphoblastic leukaemia with t(1;19)(q23;p13): clinical and cytogenetic characteristics of 47 cases from the Nordic countries treated according to NOPHO protocolsSemantic proximity Read ↗

Predictability of the t(1;19)(q23;p13) from surface antigen phenotype: implications for screening cases of childhood acute lymphoblastic leukemia for molecular analysis: a Pediatric Oncology Group studySemantic proximity Read ↗

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The translocations, t(11;19)(q23;p13.1) and t(11;19)(q23;p13.3): a cytogenetic and clinical profile of 53 patientsSemantic proximity Read ↗

Establishment and characterization of a childhood pre-B acute lymphoblastic leukemia cell line, PER-278, with chromosome translocations t(1;19) and t(1;9).Semantic proximity Read ↗

Expression of the E2A-PBX1 fusion transcripts in t(1;19)(q23;p13) and der(19)t(1;19) at diagnosis and in remission of acute lymphoblastic leukemia with different B lineage immunophenotypes.Semantic proximity Read ↗

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