Article
A genetic model for absent chylomicron formation: mice producing apolipoprotein B in the liver, but not in the intestine.
The Journal of clinical investigation - 1 Dec 1995
Young S G, Cham C M, Pitas R E, Burri B J, Connolly A, Flynn L, Pappu A S, Wong J S, Hamilton R L, Farese R V
Abstract excerpt
The formation of chylomicrons by the intestine is important for the absorption of dietary fats and fat-soluble vitamins (e.g., retinol, alpha-tocopherol). Apo B plays an essential structural role in the formation of chylomicrons in the intestine as well as the VLDL in the liver. We have developed genetically modified mice that express apo B in the liver but not in the intestine. By electron microscopy, the...
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