Article
Pathogenesis and therapeutic targeting of aberrant MYC expression in haematological cancers.
British journal of haematology - 1 Dec 2017
Schick Markus, Habringer Stefan, Nilsson Jonas A, Keller Ulrich
Abstract excerpt
Identifying and therapeutically targeting cancer cell liabilities is of utmost importance in order to improve the treatment of patients with malignancies of poor prognosis. The MYC family genes (MYC, MYCN and MYCL) are among the most deregulated proto-oncogenes in human cancer. Aberrant MYC expression is frequently associated with poor prognosis. Although many aspects of MYC-mediated tumour biology are well...
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