Article
Contribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidine.
British journal of pharmacology - 1 Apr 2001
Malmberg A B, Hedley L R, Jasper J R, Hunter J C, Basbaum A I
Abstract excerpt
There is evidence that noradrenaline contributes to the development and maintenance of neuropathic pain produced by trauma to a peripheral nerve. It is, however, unclear which subtype(s) of alpha adrenergic receptors (AR) may be involved. In addition to pro-nociceptive actions of AR stimulation, alpha(2) AR agonists produce antinociceptive effects. Here we studied the contribution of the alpha(2) AR subtypes,...
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