Article
Phenotypic changes in acute myeloid leukaemia: implications in the detection of minimal residual disease.
Journal of clinical pathology - 1 Jan 1996
Macedo A, San Miguel J F, Vidriales M B, López-Berges M C, García-Marcos M A, Gonzalez M, Landolfi C, Orfão A
Abstract excerpt
AIM: To explore the role of phenotypic changes as possible limiting factors in the immunological detection of minimal residual disease in patients with acute myeloid leukaemia (AML). METHODS: 20 relapses were evaluated, with special attention to changes in the criteria used for the definition of a phenotype as "aberrant". In all cases the same monoclonal antibody and fluorochrome were used at diagnosis and in...
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