Article
Comparison of diagnostic and relapse flow cytometry phenotypes in childhood acute lymphoblastic leukemia: implications for residual disease detection: a report from the children's oncology group.
Cytometry. Part B, Clinical cytometry - 1 Nov 2005
Borowitz Michael J, Pullen D Jeanette, Winick Naomi, Martin Paul L, Bowman W Paul, Camitta Bruce
Abstract excerpt
BACKGROUND: Flow cytometric analysis of minimal residual disease (MRD) depends on detecting phenotypically abnormal populations. However, little is known about how phenotypic shifts between diagnosis and relapse affect MRD detection in childhood acute lymphoid leukemia (ALL). METHODS: We compared diagnostic and relapse bone marrow specimens in 42 children with precursor B-ALL studied with the two-tube panel...
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