Article
Alpha 1-antitrypsin deficiency in intracranial aneurysms and cervical artery dissection.
Lancet (London, England) - 19 Feb 1994
Schievink W I, Prakash U B, Piepgras D G, Mokri B
Abstract excerpt
The pathogenesis of ruptured intracranial aneurysms and cervical artery dissections is poorly understood but may be similar in these two disorders. We report four patients with alpha 1-antitrypsin deficiency who developed a ruptured intracranial aneurysm or spontaneous dissection of the cervical internal carotid artery. Three patients were heterozygous for the deficient allele (PiMZ or PiGZ) and one was...
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