Article
The alanine/threonine polymorphism of the alpha-1-antichymotrypsin (SERPINA3) gene and ruptured intracranial aneurysms in the Japanese population.
Cerebrovascular diseases (Basel, Switzerland) - 1 Jan 2007
Krischek Boris, Akagawa Hiroyuki, Tajima Atsushi, Narita Akira, Kasuya Hidetoshi, Hori Tomokatsu, Inoue Ituro
Abstract excerpt
BACKGROUND: Serine protease inhibitor member 3 of clade A (SERPINA3), also known as alpha-1-antichymotrypsin, inhibits the activity of cathepsin G. The release of neutrophil cathepsin G (proteolytic enzyme) can destroy the vascular matrix through degradation, platelet aggregation and coagulation disorders. In a previous report there was evidence that an alanine/threonine polymorphism was associated with the risk...
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