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Article

Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2.

Genes & development - 15 Jun 1996

Hatini V, Huh S O, Herzlinger D, Soares V C, Lai E

Abstract excerpt

Metanephric mesenchyme gives rise to both the epithelial cells of the nephron and the stromal cells of the mature kidney. The function of the stroma. in kidney morphogenesis is poorly understood. We have generated mice with a null mutation in the Winged Helix (WH) transcription factor BF-2 to examine its function during development. BF-2 expression within the developing kidney is restricted to the stromal cell...

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PMID: 8666231
DOI: 10.1101/gad.10.12.1467

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