Article
A point mutation within CD45 exon A is the cause of variant CD45RA splicing in humans.
European journal of immunology - 1 Jan 1998
Zilch C F, Walker A M, Timón M, Goff L K, Wallace D L, Beverley P C
Abstract excerpt
The leukocyte common antigen (CD45) is alternatively spliced, generating various isoforms expressed on hemopoietic cells. The splicing pattern of CD45 in T cells is altered in some individuals who show abnormal expression of high molecular weight isoforms containing exon A. The variant splicing pattern was shown to be associated with heterozygosity for a silent point mutation within CD45 exon A. This C to G...
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