Article
A point mutation within CD45 exon A is the cause of variant CD45RA splicing in humans.
European journal of immunology - 1 Jan 1998
Zilch C F, Walker A M, Timón M, Goff L K, Wallace D L, Beverley P C
Abstract excerpt
The leukocyte common antigen (CD45) is alternatively spliced, generating various isoforms expressed on hemopoietic cells. The splicing pattern of CD45 in T cells is altered in some individuals who show abnormal expression of high molecular weight isoforms containing exon A. The variant splicing p...
Topics
- Alleles
- Animals
- CHO Cells
- COS Cells
- Cricetinae
- Cricetulus
- Exons
- Genes, Synthetic
- HeLa Cells
- Humans
- Hybrid Cells
- Leukocyte Common Antigens
- Mice
- Molecular Weight
- Mutagenesis, Site-Directed
- Point Mutation
- Polymerase Chain Reaction
- RNA Splicing