Trabecular bone cell proliferation ex vivo increases with donor age in the rat: it is correlated with the extent of bone loss and not with histomorphometric indices of bone formation.

Abstract excerpt

Morphometric parameters of bone formation are markedly depressed in senescent, 21-month old rats and even in middle-aged, 12-month-old animals when compared with mature, 4-month old adults. However, osteoblast-like cells obtained from the metaphyseal trabeculae of the distal femur of 21-month-old female and male rats proliferate more rapidly in primary and secondary cultures than cells from 4-month-old donors. In...

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