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Article

Age-associated changes in the stimulatory effect of transforming growth factor beta on human osteogenic colony formation.

Mechanisms of ageing and development - 1 Oct 1999

Erdmann J, Kögler C, Diel I, Ziegler R, Pfeilschifter J

Abstract excerpt

Previous studies have indicated that the mitogenic responsiveness of human bone cells may change with age. In the present study, we examined whether aging affects the capacity of transforming growth factor beta (TGF-beta) to stimulate the colony formation of human osteoprogenitor cells. Outgrowths of bone cells from 98 iliac crest biopsies were plated at a density of 25 cells/cm2 and cultured for 3 weeks in the...

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PMID: 10580693
DOI: 10.1016/s0047-6374(99)00043-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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