Article
Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes.
Cell biochemistry and function - 1 Jan 2017
Suswillo Rosemary F L, Javaheri Behzad, Rawlinson Simon C F, Dowthwaite Gary P, Lanyon Lance E, Pitsillides Andrew A
Abstract excerpt
Identifying mechanisms by which cells of the osteoblastic lineage communicate in vivo is complicated by the mineralised matrix that encases osteocytes, and thus, vital mechanoadaptive processes used to achieve load-bearing integrity remain unresolved. We have used the coculture of immunomagnetically purified osteocytes and primary osteoblasts from both embryonic chick long bone and calvariae to examine these...
Topics
- Animals
- Cell Proliferation
- Cells, Cultured
- Chick Embryo
- Chickens
- Coculture Techniques
- Gap Junctions
- Glycyrrhetinic Acid
- Osteoblasts
- Osteocytes
- Phenotype
- Skull
- Tibia