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Article

Purine deoxynucleoside metabolism in human melanoma cells with a high spontaneous mutation rate.

Mutation research - 19 Feb 1996

Musk P, Clark J M, Thompson D, Dunn I S, Christopherson R I, Szabados E, Rose S E, Parsons P G

Abstract excerpt

A human melanoma cell line (MM96L) had a spontaneous mutation rate at the HGPRT locus of approx. 7 times normal. The cells had elevated dATP and dGTP pools, lacked purine nucleoside phosphorylase (PNP) and were sensitive to killing by deoxyadenosine, deoxyinosine and related purines but not to inosine or hypoxanthine. Four other melanoma cell lines exhibited a range of nucleoside sensitivities and dNTP pool...

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Identifiers

PMID: 8657185
DOI: 10.1016/0027-5107(95)00111-5

Genes

PNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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