Article
Purine deoxynucleoside metabolism in human melanoma cells with a high spontaneous mutation rate.
Mutation research - 19 Feb 1996
Musk P, Clark J M, Thompson D, Dunn I S, Christopherson R I, Szabados E, Rose S E, Parsons P G
Abstract excerpt
A human melanoma cell line (MM96L) had a spontaneous mutation rate at the HGPRT locus of approx. 7 times normal. The cells had elevated dATP and dGTP pools, lacked purine nucleoside phosphorylase (PNP) and were sensitive to killing by deoxyadenosine, deoxyinosine and related purines but not to in...
Topics
- Alanine
- Antibiotics, Antineoplastic
- Antineoplastic Agents
- Cell Survival
- Chromatography, High Pressure Liquid
- Deoxyadenosines
- Deoxyribonucleotides
- HeLa Cells
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Inosine
- Magnetic Resonance Spectroscopy
- Melanoma
- Mutation
- Ribavirin
- Thioguanine
- Tumor Cells, Cultured