Deoxyribonucleoside triphosphate pool levels in three cell strains of human chromosome instability syndromes: ataxia telangiectasia (GM2052), Bloom's syndrome (GM1492), and Fanconi's anemia (GM368).

Abstract excerpt

Deoxyribonucleoside triphosphate (dNTP) pool sizes were determined in cell strains derived from patients with the genetic diseases ataxia telangiectasia (GM2052), Bloom's syndrome (GM1492), and Fanconi's anemia (GM368), and were compared to the dNTP pools in a normal human fibroblast cell strain (253/79). In addition, the effect of deoxythymidine on both dNTP pool levels and cell growth was examined. The three...

Topics

• Anemia, Aplastic
• Ataxia Telangiectasia
• Bloom Syndrome
• Cell Division
• Cell Line
• Culture Media
• Deoxyribonucleotides
• Fanconi Anemia
• Fibroblasts
• Humans
• Mutation