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Functional Interactions between the hBRM/hBRG1 Transcriptional Activators and the pRB Family of Proteins

1 Apr 1996

Abstract excerpt

hBRG1 and hBRM are mammalian homologs of the SNF2/SW12 yeast transcriptional activator. These proteins exist in a large multisubunit complex that likely serves to remodel chromatin and, in so doing, facilitates the function of specific transcription factors. The retinoblastoma protein (pRB) inhibits cell cycle progression by repressing transcription of specific growth-related genes. Using the yeast two-hybrid...

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PMID: 8657132
DOI: 10.1128/mcb.16.4.1576

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