Supportive evidence for the association between the T102C 5-HTR2A gene polymorphism and schizophrenia: a large-scale case-control and family-based study.

doi:10.1016/j.eurpsy.2006.06.002

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Article

Supportive evidence for the association between the T102C 5-HTR2A gene polymorphism and schizophrenia: a large-scale case-control and family-based study.

European psychiatry : the journal of the Association of European Psychiatrists - 1 Apr 2007

Golimbet V E, Lavrushina O M, Kaleda V G, Abramova L I, Lezheiko T V

Abstract excerpt

Serotonin type 2A receptors (5-HTR2A) have long been implicated in schizophrenia pathology. A decreased number of these receptors were found in postmortem brain studies of schizophrenic patients as well as in experiments using neuroimaging techniques. Molecular genetic studies revealed that the T102C polymorphism of the 5-HTR2A gene is associated with schizophrenia, with the CC genotype frequency being higher in...

Topics

Adult
Alleles
Female
Gene Frequency
Genetic Carrier Screening
Genetic Predisposition to Disease
Genetic Testing
Genotype
Humans
Male
Middle Aged
Personality Inventory
Polymorphism, Genetic
Psychotic Disorders

Source

Open in PubMed

Identifiers

PMID: 17240119
DOI: 10.1016/j.eurpsy.2006.06.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Receptor, Serotonin, 5-HT2A

Schizophrenia